Compounded Semaglutide
semaglutide (compounded) · Various compounding pharmacies
Form
Injectable vial (subcutaneous)
Frequency
Once weekly
Available Doses
Mechanism
GLP-1 receptor agonist (compounded peptide)
Manufacturer
Various compounding pharmacies
Cost
Self-Pay
$179-299/mo
Never covered by insurance. Quality varies by pharmacy. FDA testing has found potency ranging from 50-150% of labeled dose. 503B bulk compounding banned, but 503A patient-specific compounding remains legal in many states.
Side Effects
| Side Effect | Rate | Source |
|---|---|---|
| Nausea | Similar to brand-name semaglutide | Extrapolated from brand data |
| Diarrhea | Similar to brand-name semaglutide | Extrapolated from brand data |
| Vomiting | Similar to brand-name semaglutide | Extrapolated from brand data |
| Injection site reactions | May be higher due to formulation differences | FDA warnings |
Source: No independent clinical trials for compounded formulations. Side effect data extrapolated from brand-name semaglutide trials.
How It Works
If properly compounded, it works identically to brand-name semaglutide (Ozempic/Wegovy). However, the key concern is quality — without FDA manufacturing oversight, the actual dose, sterility, and stability may differ significantly from what's on the label.
Mechanism: Compounded semaglutide is the same molecule as Ozempic/Wegovy, produced by compounding pharmacies rather than Novo Nordisk. Quality, potency, and sterility vary widely by pharmacy. Semaglutide has been removed from the FDA shortage list, which ended the shortage exemption for 503B outsourcing facilities (bulk compounders). However, 503A patient-specific compounding pharmacies can still legally compound semaglutide in many states under traditional compounding rules — the situation is complex and varies by state.
Who It's For
Indication
Used for weight loss and diabetes (off-label compounded use)
Patients who have been using compounded semaglutide should consider transitioning to an FDA-approved alternative (Foundayo, Ozempic, or Wegovy) due to regulatory changes affecting 503B compounders. 503A patient-specific compounding may still be available in some states. Not recommended for new patients.
Food & Water Restrictions
✅ No Restrictions
This medication can be taken at any time of day, with or without food and water.
Switching Guides
Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Clinical trial data referenced comes from published studies and FDA prescribing information. Side effect rates are from specific clinical trials and may not reflect real-world experience. Always consult your healthcare provider before starting, stopping, or switching any medication.
⚠️ This medication is not FDA-approved. Quality, potency, and safety may vary. Discuss risks with your healthcare provider.