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FDA-ApprovedOrally disintegrating tablet (dissolves on tongue, no water needed)

Nurtec ODT

rimegepant · Pfizer/Biohaven

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Key Facts

Form

Orally disintegrating tablet (dissolves on tongue, no water needed)

Frequency

As needed for acute attacks (max 1 per day) or every other day for prevention

Available Doses

75mg

FDA Approval Date

February 27, 2020

Mechanism

CGRP receptor antagonist (gepant)

Manufacturer

Pfizer/Biohaven

Cost

Self-Pay

$900–$1,100/mo (preventive use)

With Savings Card

Pfizer co-pay savings: eligible patients may pay as little as $0/month

No generic available. Cost per tablet ~$95. Acute-only use is less expensive (only when needed). Many commercial insurance plans cover with prior authorization.

Side Effects

Side EffectRateSource
Nausea1.8%Pooled clinical trial data
Abdominal pain/discomfort1.4%FDA label
Indigestion/dyspepsia1.0%FDA label
Hypersensitivity reactions<1%Post-marketing
Dizziness<1%Clinical trials

Source: Nurtec ODT FDA Prescribing Information and Phase 3 trials (NCT03461757, NCT03732638)

Weight Loss Results

Phase 3 Acute Treatment Trial (Study 301)

Pain freedom at 2 hours: 21.2% vs 10.9% placebo; MBS freedom: 35.1% vs 26.8% placebo

Single-attack treatment · Treatment regimen (ITT)

Single-attack treatment

Randomized, double-blind, placebo-controlled trial in 1,466 adults treating a single moderate-to-severe migraine attack.

Phase 2/3 Prevention Trial (BHV3000-305)

Reduction in monthly migraine days: −4.3 vs −3.5 placebo; ≥50% responder rate: 49.1%

12 weeks · Treatment regimen (ITT)

12 weeks

Double-blind, placebo-controlled trial in 695 adults with 4–14 monthly migraine days. Nurtec 75mg taken every other day.

How It Works

Nurtec ODT blocks the CGRP receptor on trigeminal nerve endings and in the brain. During a migraine, elevated CGRP levels drive vasodilation, inflammation, and pain. By blocking the receptor, Nurtec stops these processes. For acute use, it provides rapid relief (dissolves on the tongue in seconds). For prevention, regular every-other-day dosing maintains baseline CGRP receptor blockade to reduce migraine frequency.

Mechanism: Rimegepant is a selective, small-molecule antagonist of the calcitonin gene-related peptide (CGRP) receptor. CGRP is a neuropeptide released during migraine attacks that causes vasodilation, neurogenic inflammation, and pain signaling in the trigeminovascular system. By blocking the CGRP receptor, rimegepant interrupts the migraine cascade at a highly specific target.

Who It's For

Indication

Acute treatment of migraine (with or without aura) and preventive treatment of episodic migraine in adults

Adults with episodic migraine (4–14 migraine days per month) who want a single medication for both acute and preventive treatment. Ideal for patients who have failed or cannot tolerate triptans, those with cardiovascular risk factors (unlike triptans, gepants do not cause vasoconstriction), or anyone who experiences nausea during attacks (the dissolving tablet requires no water).

Food & Water Restrictions

✅ No Restrictions

This medication can be taken at any time of day, with or without food and water.

Comparisons

Comparison

Nurtec vs Qulipta

Read comparison

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Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Clinical trial data referenced comes from published studies and FDA prescribing information. Side effect rates are from specific clinical trials and may not reflect real-world experience. Always consult your healthcare provider before starting, stopping, or switching any medication.