FDA-ApprovedCapsule

Strattera

atomoxetine · Eli Lilly

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Key Facts

Form

Capsule

Frequency

Once or twice daily

Available Doses

10mg18mg25mg40mg60mg80mg100mg

FDA Approval Date

November 26, 2002

Mechanism

Selective norepinephrine reuptake inhibitor (non-stimulant)

Manufacturer

Eli Lilly

Cost

Self-Pay

$150–$300/mo (brand); $15–$50/mo (generic)

With Savings Card

Eli Lilly patient assistance program available

Medicare

Often covered; not a controlled substance, so fewer restrictions

List Price

$320/mo

Generic atomoxetine widely available since 2017; significant cost savings

Side Effects

Side Effect	Rate	Source
Nausea	26% (adults), 10% (pediatric)	FDA label
Decreased appetite	16%	FDA label
Fatigue/somnolence	10%	FDA label
Dry mouth	20% (adults)	FDA label
Insomnia	15% (adults)	FDA label
Sexual dysfunction (erectile dysfunction)	8% (adult males)	FDA label
Dizziness	6%	FDA label

Source: Strattera FDA Prescribing Information and pooled Phase 3 trial data

Weight Loss Results

Atomoxetine Pediatric ADHD Trial

ADHD-RS improvement: −16.1 points vs −6.3 placebo

8 weeks · Treatment regimen (ITT)

8 weeks

Randomized, double-blind, placebo-controlled trial in 297 children and adolescents aged 6–16.

Atomoxetine Adult ADHD Trial

CAARS improvement: −10.5 points vs −3.5 placebo

10 weeks · Treatment regimen (ITT)

10 weeks

Double-blind, placebo-controlled trial in 536 adults. Full therapeutic effect typically reached at 4–6 weeks.

How It Works

Strattera increases norepinephrine levels in the prefrontal cortex by blocking its reuptake. This enhances attention, working memory, and executive function without affecting dopamine in the nucleus accumbens (reward center), which is why it has no abuse potential and is not a controlled substance. It works 24 hours a day, providing continuous symptom coverage, but takes 4–6 weeks to reach full effect.

Mechanism: Atomoxetine selectively inhibits the presynaptic norepinephrine transporter, increasing norepinephrine availability in the prefrontal cortex. Unlike stimulants, it has minimal effect on dopamine in reward pathways, resulting in no euphoria and no abuse potential. It was the first non-stimulant medication FDA-approved for ADHD.

Who It's For

Indication

ADHD in patients aged 6 and older (children, adolescents, and adults)

Patients with ADHD who cannot tolerate stimulants, have a history of substance abuse, or have comorbid anxiety or tic disorders. Also suitable for patients who prefer a non-controlled medication. Particularly useful when stimulant side effects (insomnia, appetite loss, tics) are intolerable.

Food & Water Restrictions

✅ No Restrictions

This medication can be taken at any time of day, with or without food and water.

Comparisons

Comparison

Strattera vs Qelbree

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Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Clinical trial data referenced comes from published studies and FDA prescribing information. Side effect rates are from specific clinical trials and may not reflect real-world experience. Always consult your healthcare provider before starting, stopping, or switching any medication.