FDA-ApprovedCapsule or chewable tablet

Vyvanse

lisdexamfetamine · Takeda

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Key Facts

Form

Capsule or chewable tablet

Frequency

Once daily (morning)

Available Doses

10mg20mg30mg40mg50mg60mg70mg

FDA Approval Date

February 23, 2007

Mechanism

Amphetamine-based prodrug (CNS stimulant)

Manufacturer

Takeda

Cost

Self-Pay

$200–$400/mo (brand); $30–$80/mo (generic)

With Savings Card

Takeda savings card available for brand Vyvanse

Medicare

Varies by plan; often covered with prior authorization

List Price

$450/mo

Generic lisdexamfetamine available since August 2023, significantly reducing cost

Side Effects

Side Effect	Rate	Source
Decreased appetite	39%	FDA label (adults)
Dry mouth	26%	FDA label (adults)
Insomnia	19%	FDA label (adults)
Headache	10%	FDA label
Irritability	10%	FDA label (pediatric)
Nausea	7%	FDA label
Increased heart rate	2–5%	FDA label
Weight loss	~4%	FDA label

Source: Vyvanse FDA Prescribing Information and pivotal Phase 3 trials (NCT00450772, NCT00687250)

Weight Loss Results

Phase 3 Pediatric ADHD Trial

ADHD-RS improvement: −18.6 points vs −5.2 placebo

4 weeks (forced-dose titration) · Treatment regimen (ITT)

4 weeks (forced-dose titration)

Randomized, double-blind, placebo-controlled study in 290 children aged 6–12. All three dose groups (30mg, 50mg, 70mg) significantly outperformed placebo.

Phase 3 Adult ADHD Trial

ADHD-RS improvement: −16.2 points vs −6.2 placebo

4 weeks (forced-dose titration) · Treatment regimen (ITT)

4 weeks (forced-dose titration)

Randomized, double-blind, placebo-controlled study in 420 adults aged 18–55.

How It Works

Vyvanse is a prodrug—therapeutically inactive until your body converts it to dextroamphetamine. This conversion happens gradually in the bloodstream (not in the gut), producing a smoother, longer-lasting effect than traditional amphetamines. Dextroamphetamine increases dopamine and norepinephrine in the prefrontal cortex, improving attention, focus, and impulse control.

Mechanism: Lisdexamfetamine is a therapeutically inactive prodrug that is converted to dextroamphetamine after oral ingestion. The enzymatic hydrolysis in the bloodstream provides a gradual, sustained release of the active drug, resulting in smoother symptom control and reduced abuse potential compared to immediate-release amphetamines.

Who It's For

Indication

ADHD in patients aged 6+ and moderate to severe binge eating disorder in adults

Children (6+), adolescents, and adults with ADHD who need a long-acting stimulant with lower abuse potential. Also approved for moderate-to-severe binge eating disorder in adults. Particularly suitable for patients who need all-day coverage (up to 14 hours) or who have concerns about stimulant misuse.

Food & Water Restrictions

✅ No Restrictions

This medication can be taken at any time of day, with or without food and water.

Comparisons

Comparison

Vyvanse vs Concerta

Read comparison

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Medical Disclaimer: This information is for educational purposes only and does not constitute medical advice. Clinical trial data referenced comes from published studies and FDA prescribing information. Side effect rates are from specific clinical trials and may not reflect real-world experience. Always consult your healthcare provider before starting, stopping, or switching any medication.