GLP-1 Dose Equivalence Chart: Every Medication Compared
The definitive dose equivalence reference for all GLP-1 medications — semaglutide, tirzepatide, and orforglipron. Based on clinical trial data.
Approximate Dose Equivalence Table
Based on similar weight loss efficacy in clinical trials:
| Efficacy Tier | Ozempic | Wegovy | Zepbound | Foundayo | Rybelsus |
|---|---|---|---|---|---|
| Starter | 0.25mg | 0.25mg | 2.5mg | 0.8mg | 3mg |
| Low | 0.5mg | 0.5mg | 5mg | 2.5mg | 7mg |
| Medium | 1.0mg | 1.0mg | 7.5mg | 5.5-9mg | 14mg |
| High | 2.0mg | 1.7mg | 10mg | 14.5mg | — |
| Maximum | — | 2.4mg | 15mg | 17.2mg | — |
⚠️ Important caveats:
- These are approximate equivalences based on weight loss efficacy, not pharmacological equivalence
- Different mechanisms mean different receptor activation patterns — a "dose equivalent" doesn't mean identical effects
- Individual response varies significantly
- Always start at the lowest dose when switching, regardless of this chart — see our safe GLP-1 switching guide
Oral GLP-1 tablets now available — from $99/mo
Done with injections? MEDVi offers GLP-1 pills and tablets alongside injectables. Take a 60-second quiz to see your options.
See Oral GLP-1 Options →Why There's No Direct Dose Conversion
Comparing GLP-1 doses directly is like comparing ibuprofen to acetaminophen — similar purpose, but different drugs with different potencies.
- Semaglutide vs tirzepatide: Different mechanisms (GLP-1 only vs GIP/GLP-1 dual)
- Semaglutide vs orforglipron: Peptide full agonist vs non-peptide small molecule agonist
- Injectable vs oral: Vastly different bioavailability (oral semaglutide absorbs ~1%)
The equivalence chart above is based on clinical outcomes (how much weight patients lose), not on receptor binding or blood levels.
Oral GLP-1 tablets now available — from $99/mo
Done with injections? MEDVi offers GLP-1 pills and tablets alongside injectables. Take a 60-second quiz to see your options.
See Oral GLP-1 Options →Done with injections? Oral GLP-1 pills available.
MEDVi offers GLP-1 tablets from $99/mo — no injection required.
Quick Medication Profiles
Ozempic (semaglutide, injectable): Weekly injection. Doses: 0.25, 0.5, 1.0, 2.0mg. FDA-approved for diabetes, widely used off-label for weight loss. Switch guides: Ozempic to Foundayo, Ozempic to Zepbound.
Wegovy (semaglutide, injectable + oral): Available as weekly injection (up to 2.4mg) or daily pill. FDA-approved for weight management. The injectable provides higher efficacy. Compare: pill vs injection. Switch: Wegovy to Foundayo.
Zepbound (tirzepatide, injectable): Weekly injection. Doses: 2.5, 5, 7.5, 10, 12.5, 15mg. Dual GIP/GLP-1. Highest efficacy (~22.5% weight loss at max dose). Switch: Zepbound to Foundayo.
Mounjaro (tirzepatide, injectable): Same drug as Zepbound. FDA-approved for diabetes. Same doses. Compare: Ozempic vs Mounjaro.
Foundayo (orforglipron, oral): Daily pill. Doses: 0.8, 2.5, 5.5, 9, 14.5, 17.2mg. Non-peptide small molecule GLP-1 receptor agonist. No food restrictions. Lowest cost. Titration schedule.
Rybelsus (semaglutide, oral): Daily pill. Doses: 3, 7, 14mg. Requires 30-min fasting. FDA-approved for diabetes. Compare: Foundayo vs Rybelsus. Switch: Rybelsus to Foundayo.
Step-by-Step: How to Make the Switch
Compare GLP-1 Providers — Oral & Injectable
These vetted providers offer both GLP-1 pills/tablets and injections. A licensed provider helps you choose the right format.
GLP-1 weight loss program — take a 60-second quiz to see if you qualify. Compounded semaglutide and tirzepatide from $99/month with provider support.
Starts at $99/mo — one of the most affordable GLP-1 programs
MedSwitcher may earn a commission from some providers. Full disclosure. This does not affect our recommendations.
Calculate Your Personalized Switch Plan
Enter your current medication and dose to get a detailed switching plan with dose mapping, timeline, and cost analysis.
Have your plan? Oral GLP-1 options start at $99/mo.
MEDVi offers GLP-1 tablets and pills — a provider helps you choose.
Frequently Asked Questions
Sources & Citations
- SUSTAIN Clinical Trials (semaglutide — Ozempic data)
- STEP Clinical Trials (semaglutide — Wegovy data)
- SURMOUNT Clinical Trials (tirzepatide — Zepbound data)
- SURPASS Clinical Trials (tirzepatide — Mounjaro data)
- ATTAIN Clinical Trials (orforglipron — Foundayo data)
- PIONEER Clinical Trials (oral semaglutide — Rybelsus data)
- FDA Prescribing Information for all listed medications
Don't miss price changes
GLP-1 prices are changing — stay ahead
Foundayo prices may increase — get alerts before they do. Track price drops, shortages, and new switching guidance without checking back manually.
- Price increase warnings before they hit
- Savings card and coupon alerts
- New switching guidance and availability updates
No spam. Unsubscribe anytime. We never share your email.
Recommended Products
Supplies and tools commonly used by GLP-1 patients during their treatment journey.
As an Amazon Associate, MedSwitcher earns from qualifying purchases. Product links do not affect our clinical recommendations.